Crystal structure of the Xrcc4 DNA repair protein and implications for end joining
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منابع مشابه
Crystal structure of the Xrcc4 DNA repair protein and implications for end joining.
XRCC4 is essential for carrying out non-homologous DNA end joining (NHEJ) in all eukaryotes and, in particular, V(D)J recombination in vertebrates. Xrcc4 protein forms a complex with DNA ligase IV that rejoins two DNA ends in the last step of V(D)J recombination and NHEJ to repair double strand breaks. XRCC4-defective cells are extremely sensitive to ionizing radiation, and disruption of the XR...
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Nonhomologous end-joining (NHEJ) repairs DNA double-strand breaks created by ionizing radiation and V(D)J recombination. To repair the broken ends, NHEJ processes noncompatible ends into a ligatable form but suppresses processing of compatible ends. It is not known how NHEJ controls polymerase and nuclease activities to act exclusively on noncompatible ends. Here, we analyzed processing indepen...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2000
ISSN: 1460-2075
DOI: 10.1093/emboj/19.22.5962